Between Friday and Sunday morning, a total of 52 people were shot in Chicago, according to police department records.
"As a mother, I am tired of the funerals. I am tired of burying our children," Chicago Mayor Lori Lightfoot tweeted, adding that the city was in the throes of a "gun violence epidemic."
The latest carnage in the Windy City comes just a week after more than 100 people were shot, 14 fatally over the Father's Day weekend.
The string of violent weekends also follows the deadliest day for shootings in Chicago in decades. On May 31, the police investigated 18 homicides, the most the city has seen in a single day in 60 years.
On Saturday, a 22-year-old woman was driving with her 20-month-old son in the neighborhood of Englewood on Chicago's South Side when just after 2 p.m. a car pulled up beside them and an occupant opened fire, according to a police incident report. The mother was grazed in the head by a bullet while her son was shot in the chest and later died at a hospital, police said. No arrests had been made as of Sunday.
The shooting came one week after 3-year-old Mekhi James was shot to death in the east Chicago neighborhood of Austin when someone pulled up alongside the car his 27-year-old stepfather was driving and opened fire, hitting the child in the back, police said.
"Everywhere you go, it is violence everywhere. You can't run from it," Mekhi's aunt, Christal Allen, told Chicago ABC station WLS.
"We do want justice, but it ain't gonna bring him back," said the boy's mother, Myesha James.
At about 9:40 p.m. this Saturday, a 10-year-old girl was hit in the head by a stray bullet that entered her apartment in the northeast Chicago neighborhood of Logan Square, police said. The girl, whose name was not released by police, was taken to the hospital, where she was pronounced dead. No arrest have been made in the incident.